Assessing the genetic contribution of Neanderthals to non-disease phenotypes in modern humans has been difficult because of the absence of large cohorts for which common phenotype information is available. 952 0 obj <>stream Using baseline phenotypes collected for 112,000 individuals by the UK Biobank, we can now elaborate on previous findings that identified associations between signatures of positive selection on Neanderthal DNA and various modern human traits but not any specific phenotypic consequences. w�� D\��̢ �s@�� ��6"� �G ��R�bMi BH؆ % a������FC���o` �S� Using baseline phenotypes collected for 112,000 individuals by the UK Biobank, we can now elaborate on previous findings that identified associations between signatures of positive selection on Neanderthal DNA and various modern human traits but not any specific phenotypic consequences. 0 Using baseline phenotypes collected for 112,000 individuals by the UK Biobank, we can now elaborate on previous findings that identified associations between signatures of positive selection on … We use cookies to help provide and enhance our service and tailor content and ads. Here, we show that Neanderthal DNA affects skin tone and hair color, height, sleeping patterns, mood, and smoking status in present-day Europeans. h�b```���@2�A�D�bl,3�$)�0�\�*aؼ�'�_��|�����~\`wb``a���怾 �+=C�k�%��2�0��f�X�~��{��`��o����$K3�T 5��1���� 䄲ؖi������:N>g���:!�_����7t�oN��xۘXT6�r�dyBD��I�S��S&������/��4�qB��a?8��K�ɭ̗�b�͋ʸ��tY/ƪu@���e���Ee���t,J�|�kQl@� &�D��m���:�2@9F ���(��`�� �aGp)& � ԉ`hG0=^�ŀ����s�a~�|��)�uY>�4� fn��\y»����/0,f�����Q������9S>&��]���I�z��0�K}�p�a���@��33��9�p�a�$�5. Neanderthal alleles contributed more variation in four behavioral phenotypes influencing sleep, mood, and smoking behaviors, suggesting that Neanderthal alleles contribute more to these traits than expected from their frequency in modern humans. Interestingly, multiple Neanderthal alleles at different loci contribute to skin and hair color in present-day Europeans, and these Neanderthal alleles contribute to both lighter and darker skin tones and hair color, suggesting that Neanderthals themselves were most likely variable in these traits. endstream endobj startxref Copyright © 2020 Elsevier B.V. or its licensors or contributors. %%EOF Here, we show that Neanderthal DNA affects skin tone and hair color, height, sleeping patterns, mood, and smoking status in present-day Europeans. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Assessing the genetic contribution of Neanderthals to non-disease phenotypes in modern humans has been difficult because of the absence of large cohorts for which common phenotype information is available. Assessing the genetic contribution of Neanderthals to non-disease phenotypes in modern humans has been difficult because of the absence of large cohorts for which common phenotype information is available. By continuing you agree to the use of cookies. We use cookies to help provide and enhance our service and tailor content and ads. h�bbd``b` �o@D���,+As@� Assessing the genetic contribution of Neanderthals to non-disease phenotypes in modern humans has been difficult because of the absence of large cohorts for which common phenotype information is available. Using baseline phenotypes collected for 112,000 individuals by the UK Biobank, we can now elaborate on previous findings that identified associations between signatures of positive selection on … Copyright © 2020 Elsevier B.V. or its licensors or contributors. Using baseline phenotypes collected for 112,000 The Contribution of Neanderthals to Phenotypic Variation in Modern Humans, https://doi.org/10.1016/j.ajhg.2017.09.010. By continuing you agree to the use of cookies. 857 0 obj <>/Filter/FlateDecode/ID[<3E26C7C5EEE21F203B59E25091C35E2C><28934106F2FE82409E17F02F3332128C>]/Index[832 121]/Info 831 0 R/Length 119/Prev 1395609/Root 833 0 R/Size 953/Type/XRef/W[1 2 1]>>stream The Contribution of Neanderthals to Phenotypic Variation in Modern Humans, https://doi.org/10.1016/j.ajhg.2017.09.010. The Contribution of Neanderthals to Phenotypic Variation in Modern Humans Michael Dannemann 1and Janet Kelso ,* Assessing the genetic contribution of Neanderthals to non-disease phenotypes in modern humans has been difficult because of the absence of large cohorts for which common phenotype information is available. %PDF-1.7 %���� Interestingly, multiple Neanderthal alleles at different loci contribute to skin and hair color in present-day Europeans, and these Neanderthal alleles contribute to both lighter and darker skin tones and hair color, suggesting that Neanderthals themselves were most likely variable in these traits. Neanderthal alleles contributed more variation in four behavioral phenotypes influencing sleep, mood, and smoking behaviors, suggesting that Neanderthal alleles contribute more to these traits than expected from their frequency in modern humans. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. 832 0 obj <> endobj
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